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Glutamate-cysteine ligase catalytic and modulator subunits as well as GSH synthetase are the three NRF2 targets involved in the GSH synthesis (242)

In patients with progressive myoclonus epilepsy, a GSTT1 -null genotype has been associated with increased risk of developing the disease where it might contribute to enhanced susceptibility to oxidative stress 60

it represents a peptidomimetic analogue of GSH that has been extensively studied

An 8-week randomized double-blind trial compared GHK-Cu in a nano-lipid carrier against Matrixyl 3000 and found a 55.8% reduction in wrinkle volume versus control serum, along with a 32.8% reduction in wrinkle depth