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Extensive analysis of the peptide's stress-protective effects revealed consistent reductions in stress hormone levels and improved stress adaptation across multiple experimental paradigms

Basta G, Lazzerini G, Massaro M, Simoncini T, Tanganelli P, Fu C, Kislinger T, Stern DM, Schmidt AM, De Caterina R: Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses

chloroform/acetone/methanol/water 50:60:25:3)

4.2 Potential of other neurotrophic factors Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor with a wide range of biological actions that positively affect the viability, proliferative activity, and migratory ability of cells in the nervous system (Revishchin et al., 2022)