dpp-4 inhibitors vs. glp-1 agonist Cardiovascular effects of inhibition: Beyond DPP4 Inhibitors vs GLP-1 Agonists

266 An additional study demonstrated that inhibition of the -aminobutyric acid receptor can promote the renewal and repair of the colonic epithelium in UC mice by regulating the Wnt/-catenin signaling pathway

Such benefits were made evident in a 2018 study in aged mice, in which eight weeks of SS-31 treatment was able to reverse age-related decline in mitochondrial ATP production, allowing for improvements in subjects exercise tolerance and a restoration of redox homeostasis (a balance between pro-oxidants and antioxidants that promotes proper muscle generation and function).24 25 Glaucoma Glaucoma, one of the leading causes of blindness globally,26 is a group of eye conditions characterized by damage to the retinal ganglion cells (RGCs).27 Since oxidative stress and mitochondrial dysfunction appear to contribute to RGC death, researchers have looked to SS-31 as a potential glaucoma treatment

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Pros: Generic versions are now available (as of 2025/2026), making it a more affordable option