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This is a known consideration in freeze-dried and frozen formulation research, where excipients such as mannitol are studied specifically to protect molecules through these phase changes, as covered in the Journal of Pharmaceutical Sciences review cited above

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A few have seen success with discontinuation or intermittent dosing, but these cases are rare and usually supported by other medications or strict lifestyle adherence

Si la fabricacin de una versin oral requiere formulaciones complejas, regmenes de dosificacin intensivos y ejerce presin sobre la cadena de suministro al exigir ms API para el mismo efecto teraputico, por qu molestarse en desarrollarla