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PD-1 agonist treatment improved airway hyperresponsiveness (AHR) in allergic asthma and suppressed lung inflammation in a humanized mouse model by controlling lung ILC2 transcriptional profiles and cytokine production and limiting type 2 innate lymphocyte (ILC2) proliferation through metabolic regulation and reducing ILC2-mediated Th2 cytokine secretion (97)

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This unusual bell-shaped dose response curve suggests the peptide operates through mechanisms that remain effective even at very low concentrations