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Dihexa has also been patented for potential use in treating Alzheimers and Parkinsons disease, though human clinical evidence remains in early stages

This practice originates from concerns about physical interactions in the gut (binding, pH changes, competition for transporters) rather than systemic pharmacokinetic conflicts

Molecular docking studies revealed that 75 made hydrogen bonds with residues Glu802, Leu648, and Pro1076, and when compared to the interaction modes of the drugs used as positive controls in the in vitro tests, 75 preserved most of the important interactions involved

Indian J Dermatol Venereol Leprol