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If constipation is intolerable on one medication, switching to the other may help, but it is not guaranteed

Practitioners hesitancy to start new medications due to perceived titration complexity, incomplete understanding of drug interactions, and uncertainty of monitoring tools and goals of care, coupled with a belief that GLP-1R agonists requiring subcutaneous injections would not be well received by patients are major barriers to optimal use

The evidence picture for BPC-157 reminds me of many natural compounds that eventually proved beneficial in clinical trials after decades of traditional use

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