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2004 Jul;287(1):G7-G17

Topical minoxidil is effective, but many people struggle with using it consistently it has to be applied twice daily and can cause scalp irritation or make the hair feel tacky, says LoGerfo

Apart from laxative abuse, melanosis coli has been reported as a consequence of long standing inflammatory bowel disease.7 The authors concluded that chronic colitis could also cause melanosis coli without laxative abuse