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Schematic representation of the main pathophysiological mechanisms (lipotoxicity, oxidative stress, inflammation, and gut-liver axis) and therapies under evaluation directed at these processes, including THR- agonists, FGF-21 analogs, pan-PPAR modulators, GLP-1 RAs, and GLP-1/GIP combinations, in addition to conventional treatments such as SGLT-2 inhibitors, metformin, statins, and vitamin E

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Despite a large number of studies, the mechanism of toxicity of selenium has not been fully understood, and the current level of knowledge indicates that the toxicity of selenium may be the result of various mechanisms

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