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In practice, patients report a deflated or gaunt appearance, cheeks that are flatter, undereye hollows that are more pronounced, deeper nasolabial folds, and a general sense that the face looks prematurely aged

The most robust evidence to date comes from the phase 2 randomised controlled trial (Jastreboff et al., NEJM , 2023)

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6.3 Patient-reported outcomes and quality of life Managing diabetes can be overwhelming, and many patients face physical, emotional, and practical challenges