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Pernicious Anaemia is caused by either the patient not producing Intrinsic Factor that is needed to bind with vitamin B12 from food before it enters the blood stream or the Intrinsic Factor is being produced but is then destroyed by antibodies to the Intrinsic Factor auto-immune Pernicious Anaemia

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At Lady Reading Hospital (LRH), Peshawar (Khyber Pakhtunkhwa Province), efficacy of Sucrosomial B12 was compared with conventional formulated B-SUB B12 (Methylcobalamin 1,000 g, manufactured by Bio Life Enterprises Nutraceuticals and marketed by Honing Pharmaceutical Laboratories, Rawalpindi, Pakistan)