safety of glp 1 drugs Comparative efficacy and GLP-1 receptor agonists for weight reduction: A model-based meta-analysis of placebo-controlled trials As GLP-1 Use Expands, Long-Term

Baruscotti M, Bucchi A, Milanesi R, Paina M, Barbuti A, Gnecchi-Ruscone T, Bianco E, Vitali-Serdoz L, Cappato R, DiFrancesco D (2017) A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia

The study found that the rodents that had this knockout gene displayed increased levels of obesity, decreased libido, and an inability to copulate

GIP is similar to GLP-1 in that its considered an incretin, a gut hormone that triggers insulin secretion, but products based on GIP had disappointed as drug candidates for diabetes

In the present study, the effect of the increased ClpB on appetite is not clear, and inhibition of glycogenesis by increased LPS has not been examined