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Justin Lathia, PhD: That's what we're working on now, right, is you get to a point in drug development where it all comes down to delivery, delivery, delivery
This is achieved through: Dietary changes : reducing refined carbohydrates, saturated fats, and overall calorie intake Regular physical activity : at least 150 minutes of moderate-intensity exercise weekly, as recommended by UK Chief Medical Officers' guidelines Managing underlying conditions : optimising control of diabetes, hypertension, and dyslipidaemia to reduce cardiovascular risk Avoiding hepatotoxic substances : ideally avoiding alcohol entirely if you have liver disease
GLP-1 RAs promote weight loss, enhancing satiety, reducing caloric intake, and delaying gastric emptying, which together reduce both the mechanical burden in intertriginous areas and systemic inflammation