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Loss of Lean Muscle Mass Rapid weight loss may result in disproportionate loss of lean muscle tissue if protein intake and resistance training are insufficient

Ortiz carefully assesses each patient to ensure they are a suitable candidate for tirzepatide injections

+ Muscle up, fat down on bimagrumab alone (-10.8 % weightall fatplus +2.5 % lean mass)

For patients with severe renal insufficiency (CrCl less than 30 mL/min, approximately corresponding to serum creatinine levels of greater than 3.0 mg/dL in men and greater than 2.5 mg/dL in women) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dose of Januvia is 25 mg once daily