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Severe or persistent GI symptoms during GLP-1 use are reasons to contact your prescribing clinician promptly, particularly if you are experiencing signs of dehydration, severe constipation, or symptoms suggestive of intestinal obstruction
Headaches, fatigue, nausea and a dry mouth are just some of the common symptoms
When to Replace Your GLP-1 Medication Replace your pen if: It was accidentally frozen It was left in a hot car It exceeded its room-temperature time limit It looks cloudy or discolored The pen shows leaks or unusual pressure When in doubt: replace it
This dual mechanism distinguishes tirzepatide from earlier GLP-1 receptor agonists such as semaglutide or liraglutide, which target only one receptor pathway
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