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While it becomes thus clear that several nutrients exert modulatory effects on (neuro)inflammatory processes, the specific pathway via which they exert these effects remains to be understood and are most likely a combination of direct and indirect processes potentially involving for example the gut microbiome [166] and the hypothalamus-pituitary-adrenal (HPA)-axis [190]

However, ephedrine is no longer allowed in dietary supplements, yet some companies still include ephedra extracts in their weight loss supplements

doi:10.1093/toxsci/kfm268 Hofmann AF

Variants in B12 metabolism genes (MTHFR, transcobalamin) and fat metabolism pathways may influence absorption and lipotropic efficacy