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Cagrilintide works differently than specific GLP-1 agonists because it activates amylin receptors, which are heterodimeric complexes of calcitonin receptor with proteins that change the function of receptors

Nat Rev Endocrinol 3 , 302310 (2007)

Although the search retrieved multicenter clinical trials that included LAC centers (166, 167), these were not incorporated as they did not focus on the region or present disaggregated results for their LAC population

[3] This matters enormously for interpretation: a result obtained with CagriSema describes cagrilintide plus a potent GLP-1 analog, and cannot be read as the effect of cagrilintide by itself