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A phase 2, randomised, double-blind, placebo-controlled, dose-ranging study evaluating retatrutide was published in the New England Journal of Medicine (NEJM) in June 2023 (Jastreboff et al

Furthermore, a recent extensive cohort study involving over 33,000 GLP-1 RA users diagnosed with diabetes over a 9-year period indicated no significant increase in pancreatic cancer risk associated with GLP-1 RA use, as evidenced by an HR of 0.50 compared to basal insulin [60]

Cardiovascular biology of the incretin system

GLP-1 medications carry important warnings and contraindications, including a boxed warning for thyroid C-cell tumors in rodents (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2)