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Because GLP-2 acts through subepithelial myofibroblasts, which are the same cell population implicated in intestinal fibrogenesis, the risk-benefit profile of GLP-2 agonism may differ substantially between mucosal UC, inflammatory ileal CD, and stricturing or penetrating CD phenotypes, and this phenotypic stratification should be a required feature of future trial design

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WhartonSBatterhamRLBhattaMBuscemiSChristensenLNFriasJPet alTwo-year effect of semaglutide 2.4mg on control of eating in adults with overweight/obesity: STEP 5

These effects are usually mild and temporary when dosing starts low