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doi: 10.1016/j.jaip.2016.03.008 [PubMed] 28365277 Macy E, Romano A, Khan D

"Efficacy and Safety of Retatrutide in Adults with Obesity." NEJM

When comparing ipamorelin vs sermorelin, ipamorelin acts on the ghrelin receptor (GHS-R1a) with high selectivity, producing a GH pulse without affecting cortisol or appetite hormones

However, neither ablating GLP-1Rexpressing nodose ganglion neurons nor selective GLP-1R knockout from VANs in adult animals reduced liraglutide- or semaglutide-induced weight loss, although GLP-1R knockout in this population modestly impaired dulaglutide-induced weight loss (37, 52, 123)