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XPO1 inhibition targets transcriptional vulnerability of FLT3-ITD+835D double mutant AML through p53 accumulation and inhibition of oncogenic transcription factors: lesson learned from CAGE sequencing of primary AML cells
It activates antioxidant enzymes such as superoxide dismutase (SOD), promotes collagen and elastin synthesis, and suppresses fibrotic pathways by inhibiting TGF-?1 signaling
This formulation builds upon the Glow Blend by adding KPV, which supports oxidative stress regulation and energy metabolism
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