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In the gastrointestinal system, GLP-1 receptor agonists slow gastric emptying, meaning food remains in the stomach for longer periods

In rare cases, particularly with oral semaglutide taken in multiple doses or concentrated injections, patients have reported confusion and extreme fatigue

There were multiple secondary objectives, divided up with respect to whether they were efficacy-related from randomization (week 20) to week 68 (cardiovascular risk factors, clinical outcome assessment, and glucose metabolism), efficacy-related from week 0 to week 68 (effects on body weight in patients who achieved the target dose during the run-in period), and safety and tolerability from week 0 to week 20 and from week 20 to week 75

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