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Low levels of glutathione can increase oxidative stress and contribute to insulin resistance

Reference: Once-weekly semaglutide 72 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial by Sean Wharton, Paula Freitas, Jran Hjelmesth, Maria Kabisch, Kristian Kandler, Ildiko Lingvay, Maria Quiroga, Julio Rosenstock and W Timothy Garvey, 14 September 2025, The Lancet Diabetes & Endocrinology

These studies underscore that the effects of serine might depend on the type of infiltrating immune cells (Tregs or Teffs) and their specific isomer, being an interesting target for supplementation in tumors with a high ratio of infiltrated Teffs/Tregs

Causes & Risk Factors Can stress contribute to a leaky gut