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The most common causes of oral pigmentations are genetic, related to ethnicity, and those caused by accidental amalgam implantation (Table 221)

Together, these primary data delineate a pathogenic axis spanning focal iron accumulation, peripheralcentral iron imbalance, and ferroptosis susceptibility in early AD. Further evidence shows that ferritin levels in cerebrospinal fluid (CSF) can predict the rate of cognitive decline and are significantly associated with both A-positivity on PET imaging and elevated t-Tau concentrations

Their unique properties enable selective binding to the cells of their origin, enhancing their targeting capabilities [157]