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Others are investigating whether adding an amylin analogue like cagrilintide to retatrutide could provide additional satiety benefits beyond what the triple agonist achieves alone

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Additional studies were identified through manual screening of reference lists from relevant review articles and clinical trial publications

470 In animal models of Apelin-13-caused cardiomyocyte hypertrophy and heart failure, NCOA4-activated ferritinophagy leads to the upregulation of SFXN1 expression, causing mitochondrial iron overload and mitochondrial ROS overproduction, increased lipid peroxidation, and ultimately, ferroptosis