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As TRAIL-expressing astrocytes have been previously demonstrated to induce T-cell apoptosis and downstream CNS inflammation, notably, the expression of this receptor was dependent on meningeal IFN expression from NK cells, and the microbiota was known to induce IFN expression from NK cells (Sanmarco et al., 2021)

Metformin stimulates the release of 5-HT from enterochromaffin cells collected by duodenal biopsy from metformin-naive individuals [68]

Delayed gastric emptying Slower transit tempers glycemic spikes and prolongs satiety

The degree varies with age, skin type, genetics, and the amount and speed of weight loss