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This medication is approved for adults with obesity or those who are overweight and have at least one weight-related condition, such as type 2 diabetes, heart disease, stroke, or obstructive sleep apnea

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Measurement of food intake, body weight, liver, and heart weight To evaluate and compare the anti-obesity effect of semaglutide, tirzepatide, and retatrutide in MC4R KO mice, we repeatedly administered vehicle (saline) to normal C57BL/6 J and MC4R KO mice, semaglutide (0.1 mg/kg), tirzepatide (0.05 mg/kg), and retatrutide (0.05 mg/kg) to MC4R KO mice

Panday, A., Sahoo, M