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This coordination reduces hepatic exposure to gut-derived inflammatory stimuli while simultaneously alleviating metabolic and immune stress through improved microbial homeostasis, intestinal barrier function, and host signaling regulation

This is consistent with the theory of local area network inhibition, which posits that excessive or unstable excitatory activity can induce homeostatic over-inhibition, thereby contributing to clinical symptomswhose precise manifestations depend on the neural networks involved

FDA-approved medicines containing semaglutide and tirzepatide are available

Based on these result, it can be concluded that manipulation of LPO derived products could present a new avenue for cancer treatment especially those fuelled by Wnt/-catenin oncogenic pathway