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Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

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Structurally, it is the only GPX isoform with a monomeric conformation and a unique catalytic tetrad including Sec, Gln81, Trp136, and Asn137 that enables it to reduce complex hydroperoxides in situ even within membranes ( Transcriptionally, GPX4 expression is promoted by Nrf2 and ATF4 in response to oxidative or endoplasmic reticulum stress

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