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elegans SLCR-46.1::mCherry was generated and expressed in S2R+ cells, and intracellular copper localization was assessed using CF4 as a copper-sensitive probe together with LysoTracker Deep Red as a lysosomal marker
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Neurotherapeutics 5:421432 Wang W, Ballatori N (1998) Endogenous glutathione conjugates: occurrence and biological functions
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Lancet 355:15181519
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The leading explanation is amplification of a pain-signaling channel on skin sensory nerves (purinergic ATP/P2X signaling). Symptoms were usually mild and eased after dose reduction
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