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In a study with osteoarthritis patients (see section 5.2 Distribution into blood cells), steady state serum concentrations were determined after intake of 200 mg Pycnogenol per day (34)

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Cellular GSH acts as a cytoprotective species via (i) its ability to provide thiol reducing equivalents in metabolic reactions and preserve a millimolar-scale reduced-thiol cytoplasmic milieu

Individuals under high oxidative stress from poor diet, alcohol use, or chronic illness may deplete their glutathione stores more rapidly, shortening the window of noticeable effects