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120 An unexpected phenotype produced by GIPR deficient ob/ob mice was that they lost weight by increasing their energy expenditure, which is surprising as their insulin levels were not significantly altered in comparison to control mice, and therefore their energy expenditure should have been similar to control mice

Possible causes include dehydration, electrolyte imbalance due to nausea or vomiting, increased sympathetic activity, or interactions with other medications

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This approach allowed for the integration of different types of evidence, broadening the understanding of the drugs clinical performance and safety profile in controlled and real-world settings