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The intrinsic apoptotic pathway is closely related to the antiapoptotic B-cell lymphoma 2 (Bcl-2) and proapoptotic Bax proteins

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Although other therapeutic agents, such as colivelin, have been shown to restore the glycocalyx and reduce the plasma concentration of syndecan-1 in sepsis (127), it is not clear whether these agents are directly integrated into the glycocalyx from the circulation or whether the glycocalyx is restored by de novo synthesis by endothelial cells

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