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This progress in scientific development enables a 1-week administration of the drug, making them an efficient alternative to other antidiabetic drugs, such as metformin, which requires two daily doses, and the updated metformin, which requires daily doses [100, 101]

The medication is typically given as a subcutaneous injection in the abdomen , thigh , or upper arm

Obviously, berberine has been shown to have a potent anti-inflammatory impact in cases of severe abdominal infection and to mitigate intestinal mucosa injury due to stressful conditions (Wang et al

It inhibits the activation of the transcription factor NF-B, reducing the production of pro-inflammatory cytokines (IL-1, TNF-, IL-6) and inflammatory mediators (PGE2, NO)