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Diagnostic cranial venous manometry was performed by interventional radiology, and revealed raised venous pressure throughout and a pressure gradient of 16 mmHg across the left sigmoid sinus without stenosis

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Interestingly, berberine, known for inducing GLP-1 and its remarkable antidiabetic properties, treatment has also shown to enrich Alistipes and enhance butyrate production (Wu et al., 2022

By activating both pathways, tirzepatide helps the pancreas release insulin when blood sugar rises, slows the movement of food through the stomach, and reduces appetite signals that trigger appetite in the brain