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The only active comparator ever used against cagrilintide monotherapy was liraglutide 3.0 mg in a Phase 2 study not tirzepatide so every ranking of the two is cross-trial inference across different populations and endpoints

Folic acid can decrease the effectiveness of some medications, including phenytoin for epilepsy or methotrexate for cancer treatment

However, the findings have to be interpreted with care

Individuals should contact their GP or a relevant specialist before considering retatrutide if they have any of the following: A personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN2): Rodent studies with GLP-1 receptor agonists have identified thyroid C-cell changes