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4 Impact on Weight Placebo-corrected weight loss reports from clinical trials suggest approximately 5% weight loss with liraglutide, 12% with semaglutide, and 18% with tirzepatide

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[5] Tips for managing Ozempic cessation People discontinuing Ozempic for weight loss may wish to consider the following tips to help manage their weight and any effects of discontinuing the medication: [3][5][7][8] Tapering: Current research about maintaining weight loss after the cessation of semaglutide is limited, but some studies suggest a tapering plan can help prevent fast weight gain