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Likewise, the ratio of tau to -synuclein in CSF has been claimed to be of high specificity in distinguishing PD from other parkinsonian syndromes or neurological controls (Parnetti et al., 2011
Hyaluronic acid can hold up to 1,000 times its weight in water, making it exceptional for hydration without heaviness ( Papakonstantinou et al., 2012 Dermato-Endocrinology )
As in PARK 1/4, PARK2, PARK7, some of the gene mutations cause early-onset PD (sometimes even juvenile-onset) with aggressive progress, while typical late-onset PD with slow progress as in sporadic disease is caused by other mutations in PARK8 (LRRK2), PARK13, and PARK17
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