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Furthermore, in animal models (rats) and in perilesional skin from vitiligo patients, the increase in IFN-, IFN-, TNF-, cytotoxic granulation marker (CD107a) (You et al., 2013

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The mechanisms of both subacute and idiosyncratic VHT remain incompletely understood, but it has been believed since the early 1980s based on limited experimental and clinical evidence [5356] that hypocarnitinaemia, subsequent imbalance between -oxidation and -oxidation, and accumulation of 4-en-VPA are involved