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AKT also phosphorylates the pro-apoptotic and anti-proliferative transcription factor FOXO1, which leads to its exclusion from the nucleus and cytosolic degradation, thereby connecting tumor cell metabolism with cell cycle progression and survival

27 In reviewing the data on cholestatic pattern liver injury, we used the definition of drug-induced cholestatic hepatitis as defined by the National Institute of Diabetes and Digestive and Kidney Disease, which includes six criteria