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2 Among these, cold exposure and fasting are well-studied paradigms that necessitate metabolic flexibility, prioritizing fatty acid oxidation over glucose catabolism to sustain systemic energy balance while sparing glucose for obligate tissues such as the brain

For this purpose, truncated HGF, anti-HGF neutralizing antibodies, and an uncleavable form of HGF have been utilized so far

This benefit extends beyond acute injuries to also potentially improving chronic conditions that involve tissues with a naturally poor blood supply, like your tendons and ligaments

Morquette et al