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Furthermore, AMPK associated energy stress and Hippo pathways are all associated with ferroptosis by regulating the PLOOH pool ( Ferroptosis and Immune Microenvironment Inducing tumor cell death is one of the effective methods to treat cancer, so inducing cancer cell ferroptosis is a feasible way for glioma treatment ( in vitro ( 74)

Complementary in vitro assessments further indicate that luteolin exhibits minimal cytotoxicity toward non-malignant cells at concentrations typically required for anti-inflammatory or antioxidant actions, supporting a favorable biological response profile (Tuli et al., 2022)