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The oxidation of specific tyrosine and methionine residues in apoA-I contributes to its loss of activity (Shao, 2012)

Under conditions of NaCl stress, spraying grapes with SA was shown to reduce the accumulation of Na + and Cl in grape leaves and roots, and increase the concentration of K + and Ca 2+ , thus reducing the damage caused by salt accumulation and improving the absorption of beneficial ions [77]

From this synthesis, we propose restoration of copper balance using copper delivery agents in combination with chaperones/chaperone mimetics, perhaps in conjunction with the neuroprotective amino acid serine, as a promising strategy in the treatment of this incurable disease