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Apparently, the number of GLP-1R in the heart is too low to detect them with ligand binding studies

SAM is most abundant in the liver, and its biosynthesis requires methionine adenosyltransferase (MAT), with MAT1A expressed in normal mature liver and MAT2A expressed in extrahepatic tissues, induced during liver growth and dedifferentiation

1 That works fine until the metabolic system is compromised by insulin resistance or obesity, at which point the brief hormonal signal is no longer enough