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Alpha arbutin works as a competitive inhibitor it mimics tyrosine, the natural substrate of tyrosinase, and occupies the enzyme's active site without damaging the melanocyte cell itself

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Individuals with genetic predispositions toward lower antioxidant reserves might theoretically benefit more from glutathione support

Patients experiencing significant gastrointestinal symptoms should be monitored to ensure they continue taking their anticoagulant as prescribed and that absorption is not compromised