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Seek urgent medical attention for sudden severe headache, headache with fever or visual changes, persistent vomiting, or symptoms suggesting pancreatitis or severe dehydration

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[16] [17] Healthcare professionals should provide clear written and verbal instructions on site rotation during treatment initiation and reinforce these principles at follow-up appointments

This refined understanding of DR as an immunoinflammatory disease provides a strong rationale for exploring immunomodulatory agents like GLP-1RAs