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Adjustments are common and expected peptide therapy is precision medicine, not one-size-fits-all

Comparison of frequencies of positive patch test reactions in the general population (Nielsen & Menn, 1992) and in eczema patients at a dermatological clinic in the same area of greater Copenhagen in 1990 a Test substance General population b Dermatological clinic c (% positive of tested) (% positive of tested) Men Women Total Men Women Total (n=279) (n=288) (n=567) (n=262) (n=410) (n=672) Potassium dichromate 0.7 0.3 0.5 1.9 2.7 2.4 Neomycin sulfate 0.0 0.0 0.0 3.4 3.7 3.6 Thiuram mixture 0.7 0.3 0.5 4.6 2.7 3.4 p-Phenylenediamine 0.0 0.0 0.0 1.9 2.7 2.4 Cobalt chloride 0.7 1.4 1.1 2.3 2.7 2.5 Benzocaine - - NT 0.4 0.7 0.6 Caine (R) (local 0.0 0.0 0.0 - - NT anaesthetic) mix Formaldehyde d - - NT 1.9 2.2 2.1 Colophony 0.4 1.0 0.7 4.6 5.4 5.1 Quinoline mix 0.4 0.3 0.4 1.9 0.5 1.0 Balsam of Peru 0.7 1.4 1.1 3.4 5.4 4.6 PPD black rubber mix 0.4 0.0 0.2 1.2 0.0 0.5 Wool alcohols 0.4 0.0 0.2 1.2 1.7 1.5 Mercapto mix 0.7 0.0 0.4 1.2 0.2 0.6 Epoxy resin 0.4 0.7 0.5 0.8 0.2 0.5 Paraben mix 0.4 0.3 0.4 0.8 0.2 0.5 p-tert-Butylphenol 1.1 1.0 1.1 0.4 1.2 0.9 formaldehyde resin Fragrance mix 1.1 1.0 1.1 6.1 7.1 6.7 Ethylenediamine 0.4 0.0 0.2 0.8 0.7 0.7 dihydrochloride e Quaternium 15 0.4 0.0 0.2 0.0 0.0 0.0 Nickel sulfate 2.2 11.1 6.7 4.2 16.1 11.5 MCI/MI 0.4 1.0 0.7 0.4 0.7 0.6 (chloro-methyl- and methyl-isothiazolinone) Table 18

The relationship of conserved genes identified in Arabidopsis to human ortholog is only clarified through experimental and mechanistic validations (Xu and Mller 2011)