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The mixture of compounds individually may be effective, however in combination they may exhibit more lipotropic activity than when administered alone in a synergistic fashion

The most common member of the genus is Berberis vulgaris but there are numerous popularly cultivated members such as Berberis thunbergii , Berberis candidula , and Berberis canadensis (American barberry)

There are also concerns that an overemphasis on natural remedies may lead to the rejection of evidence-based treatments, potentially compromising patient health outcomes

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