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Further examination with Rev-erb knockout mice, indicated increased basal nuclear factor B (NFB) and enhanced hippocampal neuroinflammatory reactivity after inflammatory challenge (Griffin et al., 2019) providing further evidence of the role and importance of circadian clock regulation on immune function

Reported incidences in those receiving a 12mg/weekly dose of retatrutide were [21]: Nausea (45% of participants) Vomiting (19%) Constipation (16%) Diarrhea (15%) Cardiac arrhythmia (11%) Fatigue (10%) Increased pancreatic enzyme (lipase) levels (8%) Injection site reactions (8%) Liver issues in 2 participants (3%) Pancreatitis in 1 participant (2%) Both tirzepatide and retatrutide share similar contraindications, including advice against their use during pregnancy and breastfeeding

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