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Population pharmacokinetics and pharmacodynamics of praziquantel in Ugandan children with intestinal schistosomiasis: higher dosages are required for maximal efficacy

PLoS one 8:e67454 Welsh N, Margulis B, Borg LA, Wiklund HJ, Saldeen J, Flodstrm M, Mello MA, Andersson A, Pipeleers DG, Hellerstrm C et al (1995) Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus

Research suggests GHK-CU has a relatively short half-life, making twice-daily administration theoretically superior for sustained gene expression effects